Towards a Raman-based diagnostic approach for characterizing cytologically indeterminate thyroid nodules

Marcos A. S. Soares de Oliveira; Yuxia Fan; Michael J. Campbell; Eric C. Huang; James W. Chan

doi:10.1117/12.2508171

4 March 2019 Towards a Raman-based diagnostic approach for characterizing cytologically indeterminate thyroid nodules

Marcos A. S. Soares de Oliveira, Yuxia Fan, Michael J. Campbell, Eric C. Huang, James W. Chan

Proceedings Volume 10881, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII; 108811I (2019) https://doi.org/10.1117/12.2508171
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Thyroid nodules are very common, and their incidence increase with age. The majority of thyroid nodules are benign, but approximately 5-15% are thyroid cancer. The cornerstone to evaluation of most thyroid nodules is a neck ultrasound followed by fine-needle aspiration (FNA) to evaluate for malignancy. Unfortunately, approximately 15-30% of FNAs are considered “indeterminate”. In these cases, cytopathologist cannot determine if the thyroid nodule is benign or malignant based on FNA alone. Although the majority of these “indeterminate” nodules are ultimately benign, majority of these patients require thyroidectomies to rule out cancer. This puts the patient at unnecessary risk of surgical complications and increases health care costs. A better method is needed to help physicians determine the risk of malignancy in patients with indeterminate thyroid nodules. In recent years there has been much interest in the use of optical diagnostic in cancer detection. Recent investigations potentially suggest that Raman spectroscopy (RS) can be used as a clinical tool that could confer great patient advantage with minimally invasive, non-destructive, rapid and accurate diagnosis. In this study, we investigate the use of line-scan RS and imaging in combination with multivariate statistical analysis of the spectral data for objective identification and classification of single cells isolated from frozen samples of different types of human thyroid nodules. Preliminary results indicate a high sensitivity and specificity for identifying different cell types.

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Marcos A. S. Soares de Oliveira, Yuxia Fan, Michael J. Campbell, Eric C. Huang, and James W. Chan "Towards a Raman-based diagnostic approach for characterizing cytologically indeterminate thyroid nodules", Proc. SPIE 10881, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII, 108811I (4 March 2019); https://doi.org/10.1117/12.2508171

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KEYWORDS

Raman spectroscopy

Cancer

Fine needle aspiration

Diagnostics

Principal component analysis

Tissues

Pathology

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