Monitoring cerebral and cutaneous hemodynamics through in vivo skull and skin optical clearing techniques (Conference Presentation)

Wei Feng; Chao Zhang; Dan Zhu

doi:10.1117/12.2507219

4 March 2019 Monitoring cerebral and cutaneous hemodynamics through in vivo skull and skin optical clearing techniques (Conference Presentation)

Wei Feng, Chao Zhang, Dan Zhu

Author Affiliations +

Proceedings Volume 10877, Dynamics and Fluctuations in Biomedical Photonics XVI; 108770O (2019) https://doi.org/10.1117/12.2507219
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In vivo monitoring cerebral and cutaneous hemodynamics is of great important to investigate brain and peripheral circulation system functional responses to physiopathologic stimulations. Nevertheless, the high scattering characteristics of skull and skin severely limit optical imaging performance. Fortunately, in vivo tissue optical clearing techniques can efficiently overcome these problem. In this work, we combined hyperspectral imaging (HSI) and laser speckle contrast imaging (LSCI) to simultaneously monitor the changes in cortical and cutaneous microvascular blood oxygen saturation and blood flow under assistance of in vivo skull and skin optical clearing techniques, and quantitatively compared the difference between cerebral and cutaneous arteriovenous functional responses when the hypoxic stimulations was performed. The results show that the cerebral arteriovenous blood flow response is much more sensitive to the hypoxic stimulations comparing with that of cutaneous vessels. As for the arteriovenous blood oxygen response, there are only small differences between cerebral and cutaneous vessels to the instant hypoxia, but the blood oxygen level of cerebral vessels recovers faster than that of cutaneous vessels after the hypoxic stimulation. This work provides a feasible solution to realize visualization of in vivo monitoring cerebral and cutaneous microvascular reactivity with minimal invasiveness. Monitoring of microvascular reactivity with high resolution is of great significance to the study of vascular dysfunction in some peripheral vascular and cerebrovascular diseases.

Conference Presentation

Citation Download Citation

Wei Feng, Chao Zhang, and Dan Zhu "Monitoring cerebral and cutaneous hemodynamics through in vivo skull and skin optical clearing techniques (Conference Presentation)", Proc. SPIE 10877, Dynamics and Fluctuations in Biomedical Photonics XVI, 108770O (4 March 2019); https://doi.org/10.1117/12.2507219

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

In vivo imaging

Optical clearing

Skin

Skull

Hemodynamics

Blood circulation

Blood oxygen saturation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years