Immune Response Following Photodynamic Therapy For Bladder Cancer

Unyime O. Nseyo; Raymond K. Whalen; Matthew R. Duncan; Brian Berman; Scott Lundahl

doi:10.1117/12.978005

13 June 1989 Immune Response Following Photodynamic Therapy For Bladder Cancer

Unyime O. Nseyo, Raymond K. Whalen, Matthew R. Duncan, Brian Berman, Scott Lundahl

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978005
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

This study was undertaken to determine if photodynamic therapy (PDT) produces an immunologic response in patients treated for bladder cancer. Gamma interferon, interleukin 1-beta, interleukin 2 and tumor necrosis factor-alpha were assayed in the urine of four patients treated with photodynamic therapy for bladder cancer, in seven patients undergoing transurethral procedures, and in five healthy control subjects. Quantifiable concentrations of all cytokines, except gamma interferon, were measured in urine samples from the PDT patients treated with the highest light energies, while no urinary cytokines were found in the PDT patient who received the lowest light energy or in the control subjects. These findings suggest that a local immunologic response may occur following PDT for bladder cancer. Such an immunologic response activated by PDT may be an additional mechanism involved in bladder tumor destruction.

Citation Download Citation

Unyime O. Nseyo, Raymond K. Whalen, Matthew R. Duncan, Brian Berman, and Scott Lundahl "Immune Response Following Photodynamic Therapy For Bladder Cancer", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978005

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