Visualization of nanoconstructions with DNA-Aptamers for targeted molecules binding on the surface of screen-printed electrodes

Ivan N. Lapin; Anastasiia V. Shabalina; Valery A. Svetlichyi; Olga S. Kolovskaya

doi:10.1117/12.2304745

16 April 2018 Visualization of nanoconstructions with DNA-Aptamers for targeted molecules binding on the surface of screen-printed electrodes

Ivan N. Lapin, Anastasiia V. Shabalina, Valery A. Svetlichyi, Olga S. Kolovskaya

Author Affiliations +

Proceedings Volume 10614, International Conference on Atomic and Molecular Pulsed Lasers XIII; 106141R (2018) https://doi.org/10.1117/12.2304745
Event: XIII International Conference on Atomic and Molecular Pulsed Lasers, 2017, Tomsk, Russia

Abstract

Nanoconstructions of gold nanoparticles (NPs) obtained via pulsed laser ablation in liquid with DNA-aptamer specific to protein tumor marker were visualized on the surface of screen-printed electrode using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). AuNPs/aptamer nanoconstuctions distribution on the solid surface was studied. More uniform coverage of the carbon electrode surface with the nanoconstuctions was showed in comparison with DNA-aptamer alone on the golden electrode surface. Targeted binding of the tumor marker molecules with the AuNPs/DNA-aptamer nanoconstuctions was approved.

Citation Download Citation

Ivan N. Lapin, Anastasiia V. Shabalina, Valery A. Svetlichyi, and Olga S. Kolovskaya "Visualization of nanoconstructions with DNA-Aptamers for targeted molecules binding on the surface of screen-printed electrodes", Proc. SPIE 10614, International Conference on Atomic and Molecular Pulsed Lasers XIII, 106141R (16 April 2018); https://doi.org/10.1117/12.2304745

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