In vivo observation of transient photoreceptor movement correlated with oblique light stimulation

Yiming Lu; Changgeng Liu; Xincheng Yao

doi:10.1117/12.2287262

20 February 2018 In vivo observation of transient photoreceptor movement correlated with oblique light stimulation

Yiming Lu, Changgeng Liu, Xincheng Yao

Proceedings Volume 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI; 104971M (2018) https://doi.org/10.1117/12.2287262
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for high resolution assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its fast time course and sub-cellular signal magnitude. By developing a line-scanning and virtually structured detection based super-resolution ophthalmoscope, we report here in vivo observation of TRP in frog retina. In vivo characterization of TRP time course and magnitude were implemented by using variable light stimulus intensities.

Citation Download Citation

Yiming Lu, Changgeng Liu, and Xincheng Yao "In vivo observation of transient photoreceptor movement correlated with oblique light stimulation ", Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 104971M (20 February 2018); https://doi.org/10.1117/12.2287262

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