A calibrated iterative reconstruction for quantitative photoacoustic tomography using multi-angle light-sheet illuminations

Yihan Wang; Tong Lu; Songhe Zhang; Shaoze Song; Bingyuan Wang; Jiao Li; Huijuan Zhao; Feng Gao

doi:10.1117/12.2290215

19 February 2018 A calibrated iterative reconstruction for quantitative photoacoustic tomography using multi-angle light-sheet illuminations

Yihan Wang, Tong Lu, Songhe Zhang, Shaoze Song, Bingyuan Wang, Jiao Li, Huijuan Zhao, Feng Gao

Author Affiliations +

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104943C (2018) https://doi.org/10.1117/12.2290215
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Quantitative photoacoustic tomography (q-PAT) is a nontrivial technique can be used to reconstruct the absorption image with a high spatial resolution. Several attempts have been investigated by setting point sources or fixed-angle illuminations. However, in practical applications, these schemes normally suffer from low signal-to-noise ratio (SNR) or poor quantification especially for large-size domains, due to the limitation of the ANSI-safety incidence and incompleteness in the data acquisition. We herein present a q-PAT implementation that uses multi-angle light-sheet illuminations and a calibrated iterative multi-angle reconstruction. The approach can acquire more complete information on the intrinsic absorption and SNR-boosted photoacoustic signals at selected planes from the multi-angle wide-field excitations of light-sheet. Therefore, the sliced absorption maps over whole body can be recovered in a measurementflexible, noise-robust and computation-economic way. The proposed approach is validated by the phantom experiment, exhibiting promising performances in image fidelity and quantitative accuracy.

Citation Download Citation

Yihan Wang, Tong Lu, Songhe Zhang, Shaoze Song, Bingyuan Wang, Jiao Li, Huijuan Zhao, and Feng Gao "A calibrated iterative reconstruction for quantitative photoacoustic tomography using multi-angle light-sheet illuminations", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104943C (19 February 2018); https://doi.org/10.1117/12.2290215

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KEYWORDS

Absorption

Calibration

Acquisition tracking and pointing

Inverse optics

Photoacoustic tomography

3D modeling

Finite element methods

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