A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography

Guoyan Yin; Limin Zhang; Yanqi Zhang; Han Liu; Wenwen Du; Wenjuan Ma; Huijuan Zhao; Feng Gao

doi:10.1117/12.2287821

19 February 2018 A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography

Guoyan Yin, Limin Zhang, Yanqi Zhang, Han Liu, Wenwen Du, Wenjuan Ma, Huijuan Zhao, Feng Gao

Author Affiliations +

Proceedings Volume 10486, Design and Quality for Biomedical Technologies XI; 1048613 (2018) https://doi.org/10.1117/12.2287821
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Pharmacokinetic diffuse fluorescence tomography (DFT) can describe the metabolic processes of fluorescent agents in biomedical tissue and provide helpful information for tumor differentiation. In this paper, a dynamic DFT system was developed by employing digital lock-in-photon-counting with square wave modulation, which predominates in ultra-high sensitivity and measurement parallelism. In this system, 16 frequency-encoded laser diodes (LDs) driven by self-designed light source system were distributed evenly in the imaging plane and irradiated simultaneously. Meanwhile, 16 detection fibers collected emission light in parallel by the digital lock-in-photon-counting module. The fundamental performances of the proposed system were assessed with phantom experiments in terms of stability, linearity, anti-crosstalk as well as images reconstruction. The results validated the availability of the proposed dynamic DFT system.

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Guoyan Yin, Limin Zhang, Yanqi Zhang, Han Liu, Wenwen Du, Wenjuan Ma, Huijuan Zhao, and Feng Gao "A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography", Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI, 1048613 (19 February 2018); https://doi.org/10.1117/12.2287821

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KEYWORDS

Modulation

Dynamical systems

Imaging systems

Signal detection

Fluorescence tomography

Field programmable gate arrays

Current controlled current source

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