Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat unresectable and metastatic cancers and produce and cancer vaccine effect

Tuan Vo-Dinh; Brant Inman; Paolo Maccarini; Gregory Palmer; Yang Liu

doi:10.1117/12.2300089

12 February 2018 Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat unresectable and metastatic cancers and produce and cancer vaccine effect

Tuan Vo-Dinh, Brant Inman, Paolo Maccarini, Gregory Palmer, Yang Liu

Author Affiliations +

Proceedings Volume 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI; 1048408 (2018) https://doi.org/10.1117/12.2300089
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). Their multiple sharp branches acting like “lightning rods” can convert safely and efficiently light into heat. As with other nanoparticles, GNS sizes can be controlled so that they passively accumulate in tumors due to the enhanced permeability and retention (EPR) effect of tumor vasculature. This feature improves tumor-targeting precision and permits the use of reduced laser energy required to destroy the targeted cancer cells. The ability to selectively heat tumor areas where GNS are located while keeping surrounding healthy tissues at significantly lower temperatures offers significant advantages over other thermal therapies. GNS-mediated photothermal therapy combined with checkpoint immunotherapy was shown to reverse tumor-mediated immunosuppression, leading to the treatment of not only primary tumors but also cancer metastasis as well as inducing effective long-lasting immunity, i.e. an anticancer ‘vaccine’ effect.

Citation Download Citation

Tuan Vo-Dinh, Brant Inman, Paolo Maccarini, Gregory Palmer, and Yang Liu "Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat unresectable and metastatic cancers and produce and cancer vaccine effect", Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048408 (12 February 2018); https://doi.org/10.1117/12.2300089

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