Gold nanoparticle-mediated laser stimulation causes a complex stress signal in neuronal cells

Sonja Johannsmeier; Patrick Heeger; Mitsuhiro Terakawa; Stefan Kalies; Alexander Heisterkamp; Tammo Ripken; Dag Heinemann

doi:10.1117/12.2284174

1 August 2017 Gold nanoparticle-mediated laser stimulation causes a complex stress signal in neuronal cells

Sonja Johannsmeier, Patrick Heeger, Mitsuhiro Terakawa, Stefan Kalies, Alexander Heisterkamp, Tammo Ripken, Dag Heinemann

Author Affiliations +

Proceedings Volume 10417, Medical Laser Applications and Laser-Tissue Interactions VIII; 104170B (2017) https://doi.org/10.1117/12.2284174
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

Gold nanoparticle mediated laser stimulation of neuronal cells allows for cell activation on a single-cell level. It could therefore be considered an alternative to classical electric neurostimulation. The physiological impact of this new approach has not been intensively studied so far. Here, we investigate the targeted cell’s reaction to a laser stimulus based on its calcium response. A complex cellular reaction involving multiple sources has been revealed.

Citation Download Citation

Sonja Johannsmeier, Patrick Heeger, Mitsuhiro Terakawa, Stefan Kalies, Alexander Heisterkamp, Tammo Ripken, and Dag Heinemann "Gold nanoparticle-mediated laser stimulation causes a complex stress signal in neuronal cells", Proc. SPIE 10417, Medical Laser Applications and Laser-Tissue Interactions VIII, 104170B (1 August 2017); https://doi.org/10.1117/12.2284174

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