Assessing corneal viscoelasticity after crosslinking at different IOP by noncontact OCE and a modified Lamb wave model

Zhaolong Han; Jiasong Li; Manmohan Singh; Chen Wu; Chih-hao Liu; Raksha Raghunathan; Salavat R. Aglyamov; Srilatha Vantipalli; Michael D. Twa; Kirill V. Larin

doi:10.1117/12.2251784

8 February 2017 Assessing corneal viscoelasticity after crosslinking at different IOP by noncontact OCE and a modified Lamb wave model

Zhaolong Han, Jiasong Li, Manmohan Singh, Chen Wu, Chih-hao Liu, Raksha Raghunathan, Salavat R. Aglyamov, Srilatha Vantipalli, Michael D. Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 10045, Ophthalmic Technologies XXVII; 1004502 (2017) https://doi.org/10.1117/12.2251784
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

UV-A/riboflavin collagen cross-linking (UV-CXL) is a clinical treatment for keratoconus that stiffens mechanically degraded corneal tissue. On the other hand, the intraocular pressure (IOP) can also affect the measured cornea elasticity. However, the combined effects of CXL at different IOPs on the corneal biomechanical properties are not well understood. In this work, the feasibility of assessing the viscoelasticity of the porcine cornea before and after CXL at various IOPs was investigated by using a noncontact method of optical coherence elastography (OCE) and a modified Lamb wave model. The modified wave model was first verified by comparison with finite element modeling, and then utilized to quantify the viscoelasticity of porcine corneas in the whole eye-globe configuration before and after CXL treatment at various IOPs. The results show that the elasticity of the cornea increased after CXL and that corneal stiffness was linear as a function of IOP. At IOPs of 15, 20, 25, and 30 mmHg, the relative increase in Young’s modulus after CXL was ~109%, ~86%, ~64%, and ~79%, respectively, while the shear viscosity decreased by ~86%, ~84%, ~83%, and ~81%. The modified Lamb wave model and OCE show promise for quantifying corneal viscoelasticity, which could provide a basis for customized CXL therapies and accurate disease detection.

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Zhaolong Han, Jiasong Li, Manmohan Singh, Chen Wu, Chih-hao Liu, Raksha Raghunathan, Salavat R. Aglyamov, Srilatha Vantipalli, Michael D. Twa, and Kirill V. Larin "Assessing corneal viscoelasticity after crosslinking at different IOP by noncontact OCE and a modified Lamb wave model", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004502 (8 February 2017); https://doi.org/10.1117/12.2251784

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KEYWORDS

Cornea

Finite element methods

Tissues

Dispersion

Protactinium

Elastography

Eye models

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