Cardiorenal damage in heart failure with preserved ejection fraction: a spectroscopic study

Leonardo Pioppi; Gustavo Jose Justo Silva; Reza Parvan; Marco Paolantoni; Alessandro Cataliotti; Paola Sassi

doi:10.1117/12.3022282

20 June 2024 Cardiorenal damage in heart failure with preserved ejection fraction: a spectroscopic study

Leonardo Pioppi, Gustavo Jose Justo Silva, Reza Parvan, Marco Paolantoni, Alessandro Cataliotti, Paola Sassi

Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC1300606 (2024) https://doi.org/10.1117/12.3022282
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Heart Failure with Preserved Ejection Fraction (HFpEF) is a severe medical condition. Concurrent pathologies linked with HFpEF create a complex scenario that contributes to structural and functional abnormalities in the heart and kidneys—the principal end organs affected by HFpEF. In this study, we assessed the effectiveness of a synergistic application of FTIR and Raman spectroscopy and multivariate/univariate statistical analyses to yield valuable pathophysiological insights in a rat model of heart failure. Peculiar biochemical differences were detected in the two organs demonstrating heightened sensitivity of these techniques towards the distinctive HFpEF phenotype.

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Citation Download Citation

Leonardo Pioppi, Gustavo Jose Justo Silva, Reza Parvan, Marco Paolantoni, Alessandro Cataliotti, and Paola Sassi "Cardiorenal damage in heart failure with preserved ejection fraction: a spectroscopic study", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC1300606 (20 June 2024); https://doi.org/10.1117/12.3022282

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