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13 March 2024 Femtosecond fieldoscopy
Hanieh Fattahi
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Proceedings Volume PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024; PC128550J (2024) https://doi.org/10.1117/12.2691585
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The indispensability of label-free microscopy in rendering detailed cellular observations of biological processes is well-established. This talk introduces an innovative progression in this field towards a super-resolution, label-free microscope that employs an ambient-air, field detector. In this technique, by employing bright, ultra-broadband, femtosecond laser pulses at near petahertz frequencies, molecular vibrations are driven coherently and efficiently. The same laser provides optical pulses with ultrashort duration to directly access and detects the field oscillations of the emitted molecular response in space and time. This novel metrology allows for simultaneous and broadband detection of the entire molecular fingerprint and beyond, with high detection sensitivity, dynamic range, and spatial resolution.
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Hanieh Fattahi "Femtosecond fieldoscopy", Proc. SPIE PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024, PC128550J (13 March 2024); https://doi.org/10.1117/12.2691585
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KEYWORDS
Femtosecond phenomena
Microscopy
Pulse signals
Femtosecond pulse shaping
Diffraction limit
Nonlinear crystals
Spatial resolution
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