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13 March 2024 Biomechanical interaction studies of the perilimbal sclera and aqueous veins during intraocular pressure regulation
Linyu Ni, Alexus Warchock, Erik Krawczyk, Wonsuk Kim, Sayoko Moroi, Alan Argento, Guan Xu
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421I (2024) https://doi.org/10.1117/12.3001025
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Glaucoma is a leading cause of blindness. Previously, we quantified the deformations in scleral tissue components through a PAM-FEA methodology. This study furthers our examination of perilimbal sclera (PLS) and aqueous veins in intraocular pressure (IOP) regulation using ex vivo porcine eyes. Our results reveal that the cross-sectional area change of the aqueous veins and strain of PLS are strongly and positively correlated with the steady-state IOP (n=8, R2=0.90, R2=0.57, respectively) and the IOP elevation rate at a constantly increasing flow rate (n=8, R2=0.89, R2=0.58, respectively). These insights bolster our supposition that a stiffer PLS can lead to heightened IOP and reduced ocular adaptability to aqueous outflow, primarily due to restrictions on aqueous vein dilation.
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Linyu Ni, Alexus Warchock, Erik Krawczyk, Wonsuk Kim, Sayoko Moroi, Alan Argento, and Guan Xu "Biomechanical interaction studies of the perilimbal sclera and aqueous veins during intraocular pressure regulation", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421I (13 March 2024); https://doi.org/10.1117/12.3001025
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KEYWORDS
Veins
Sclera
Biomechanics
Deformation
Finite element methods
Glaucoma
Tissues
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