Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo

Hailong He; Christine Schoenmann; Ulf Darsow; Vasilis Ntziachristos; Ludwig Englert

doi:10.1117/12.3001889

13 March 2024 Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo

Hailong He, Christine Schoenmann, Ulf Darsow, Vasilis Ntziachristos, Ludwig Englert

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284202 (2024) https://doi.org/10.1117/12.3001889
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

To enable high-resolution imaging of melanoma vasculature in humans, we developed fast raster-scanning optoacoustic mesoscopy (FRSOM) using an illumination scheme that is co-axial with a high-sensitivity ultrasound detector path, yielding 15 second single-breath-hold scans that minimize motion artifacts. We apply this FRSOM to image 10 melanomas and 10 benign nevi in vivo, showing marked differences between malignant and benign lesions, supporting the possibility to use biomarkers extracted from RSOM imaging of vasculature for lesion characterization to improve diagnostics.

Conference Presentation

Citation Download Citation

Hailong He, Christine Schoenmann, Ulf Darsow, Vasilis Ntziachristos, and Ludwig Englert "Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284202 (13 March 2024); https://doi.org/10.1117/12.3001889

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