Vibrational biospectroscopy of blood plasma: an alternative approach to endometrial cancer diagnosis and screening

Roberta Schiemer; Jessica Grant; David Furniss; Sendy Phang; Angela B. Seddon; Ioan Notingher; William Atiomo; Ketankumar Gajjar

doi:10.1117/12.2689565

13 March 2024 Vibrational biospectroscopy of blood plasma: an alternative approach to endometrial cancer diagnosis and screening

Roberta Schiemer, Jessica Grant, David Furniss, Sendy Phang, Angela B. Seddon, Ioan Notingher, William Atiomo, Ketankumar Gajjar

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Proceedings Volume PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC128360D (2024) https://doi.org/10.1117/12.2689565
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Endometrial cancer is the sixth most common cancer and the fourth leading cause of death amongst women worldwide. Currently there are no screening strategies successfully implemented in clinical practice for the general population. Present diagnostic approaches are invasive, costly and time consuming. Here, we present results of a simple blood test showing promise for endometrial cancer detection. Both Raman and FtIR-ATR (Fourier transform Infrared Attenuated Total Reflection) spectroscopies, of blood plasma taken from patients with and without endometrial cancer, as ascertained by histopathology, are shown to yield discrimination of endometrial cancer. Spectral data classification is performed using Quasar open-source software.

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Roberta Schiemer, Jessica Grant, David Furniss, Sendy Phang, Angela B. Seddon, Ioan Notingher, William Atiomo, and Ketankumar Gajjar "Vibrational biospectroscopy of blood plasma: an alternative approach to endometrial cancer diagnosis and screening", Proc. SPIE PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC128360D (13 March 2024); https://doi.org/10.1117/12.2689565

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KEYWORDS

Cancer

Blood

Plasma

Vibration

Raman spectroscopy

Diagnostics

Histopathology

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