Cutaneous pharmacokinetic and pharmacodynamic imaging with coherent Raman scattering (Conference Presentation)

Conor L. Evans

doi:10.1117/12.2647916

15 March 2023 Cutaneous pharmacokinetic and pharmacodynamic imaging with coherent Raman scattering (Conference Presentation)

Conor L. Evans

Author Affiliations +

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920X (2023) https://doi.org/10.1117/12.2647916
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Measurement of the permeation and distribution of topical drugs remains challenging, in particular within the outmost layer of the skin known as the epidermis. As the epidermis serves as the skin’s major barrier, this makes it difficult, in both preclinical and clinical settings, to quantify the flux and flow of active pharmaceutical compounds into skin. We have developed coherent Raman imaging methods for the three-dimensional mapping and quantification of drug permeation within the epidermis over time, allowing for the visualization of drug permeation and localization alongside microscale measurements of pharmacokinetic parameters including Tmax, Cmax, and AUC. Coherent Raman imaging can additionally be used for the active measurement of skin response to drug intervention, with machine learning methods providing new and unique insight to pharmacodynamics. This information is critical for drug discovery, the development of new topical drugs, and generic topical products.

Conference Presentation

Citation Download Citation

Conor L. Evans "Cutaneous pharmacokinetic and pharmacodynamic imaging with coherent Raman scattering (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920X (15 March 2023); https://doi.org/10.1117/12.2647916

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KEYWORDS

Coherence imaging

Skin

Raman scattering

Raman spectroscopy

In vitro testing

Drug discovery

In vivo imaging

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