Longitudinal study of rheumatoid arthritis development in rodent model by photoacoustic and Doppler ultrasound

Xiaorui Peng; Zhanpeng Xu; Aaron Dentinger; Steven Gray; Soumya Ghose; Shivangi Kewalramani; Janggun Jo; Nada Abdulaziz; Guan Xu; Girish Gandikota; David Mills; Xueding Wang

doi:10.1117/12.2650248

9 March 2023 Longitudinal study of rheumatoid arthritis development in rodent model by photoacoustic and Doppler ultrasound

Xiaorui Peng, Zhanpeng Xu, Aaron Dentinger, Steven Gray, Soumya Ghose, Shivangi Kewalramani, Janggun Jo, Nada Abdulaziz, Guan Xu, Girish Gandikota, David Mills, Xueding Wang

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791D (2023) https://doi.org/10.1117/12.2650248
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

A longitudinal study on both 3D and 2D photoacoustic and Doppler ultrasound images of rat leg rheumatoid arthritis development has been performed using an automatic imaging system based on a GE HealthCare VividTM E95 unit with a L8-18i-D probe, an OPOTEK tunable laser system, and a Universal Robots UR3 robotic arm. Daily imaging of ankle bones was performed starting from day 0 when the lyophilized Mycobacterium butyricum was injected to induce the disease. Although both photoacoustic and Doppler ultrasound can confirm the disease development, photoacoustic imaging is more sensitive to microvasculature and enables earlier detection of inflammation than Doppler ultrasound.

Conference Presentation

Citation Download Citation

Xiaorui Peng, Zhanpeng Xu, Aaron Dentinger, Steven Gray, Soumya Ghose, Shivangi Kewalramani, Janggun Jo, Nada Abdulaziz, Guan Xu, Girish Gandikota, David Mills, and Xueding Wang "Longitudinal study of rheumatoid arthritis development in rodent model by photoacoustic and Doppler ultrasound", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791D (9 March 2023); https://doi.org/10.1117/12.2650248

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available