Fast reconstruction algorithms and instrumentation for spatial frequency domain fluorescence diffuse optical imaging

Sang Hoon Chong; Vadim A. Markel; Ashwin B. Parthasarathy; Yi Hong Ong; Kenneth Abramson; Frank A. Moscatelli; Arjun G. Yodh

doi:10.1117/12.2647303

17 March 2023 Fast reconstruction algorithms and instrumentation for spatial frequency domain fluorescence diffuse optical imaging

Sang Hoon Chong, Vadim A. Markel, Ashwin B. Parthasarathy, Yi Hong Ong, Kenneth Abramson, Frank A. Moscatelli, Arjun G. Yodh

Author Affiliations +

Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC1236109 (2023) https://doi.org/10.1117/12.2647303
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The current fluorescence image-guided surgery technique does not provide accurate estimates of target depth and transverse margins of fluorescing tumors. We adapted Spatial Frequency Domain Fluorescence Diffuse Optical Tomography to rapidly acquire the depth and transverse margins of fluorescent inclusions in a turbid media in two steps. First, we derive estimates of depth from normalized fluorescence responses to the spatially modulated light patterns. Second, using the estimated depth, we reconstruct the transverse margin in the target plane. We demonstrate the performance of our instrumentation and approach using a series of phantom experiments.

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Sang Hoon Chong, Vadim A. Markel, Ashwin B. Parthasarathy, Yi Hong Ong, Kenneth Abramson, Frank A. Moscatelli, and Arjun G. Yodh "Fast reconstruction algorithms and instrumentation for spatial frequency domain fluorescence diffuse optical imaging", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC1236109 (17 March 2023); https://doi.org/10.1117/12.2647303

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KEYWORDS

Luminescence

Reconstruction algorithms

Diffuse optical imaging

3D image processing

Detection and tracking algorithms

Diffuse optical tomography

Image-guided intervention

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