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Raman optical activity (ROA) is a powerful tool for identifying the absolute conformational information and behavior of chiral molecules in aqueous solutions, but suffers from low sensitivity. Here we report our development of a silicon nanodisk array that tailors a chiral field to significantly increase the interaction between the excitation light and chiral molecules via exploiting a dark mode. Specifically, we used the array with pairs of chemical and biological enantiomers to show >100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurements. Our silicon nanodisk array opens a cost-effective way for conformational analysis of trace chiral molecules.
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