Optical imaging of metabolic profiles in responder and non-responder human lung tumors

Paola Monterroso Diaz; Narasimhan Rajaram; Kyle P. Quinn

doi:10.1117/12.2609823

7 March 2022 Optical imaging of metabolic profiles in responder and non-responder human lung tumors

Paola Monterroso Diaz, Narasimhan Rajaram, Kyle P. Quinn

Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC1194408 (2022) https://doi.org/10.1117/12.2609823
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Two-photon microscopy was used to investigate responder vs non-responder NSCLC tumors. We received twenty-four NSCLC specimens, resected before therapy, and classified them as responder and non-responder according to subject-detail reports. Two-photon microscopy was used to determine an optical redox ratio and mean NADH lifetime data for each sample. The optical redox ratio revealed a decrease in the responder group when compared to the non-responder tumors, whereas the responder tumor group presented a longer mean NADH lifetime when compared to non-responder group. Our current results point to the potential of metabolic imaging in providing information on treatment response of tumors prior to receiving therapy.

Conference Presentation

Citation Download Citation

Paola Monterroso Diaz, Narasimhan Rajaram, and Kyle P. Quinn "Optical imaging of metabolic profiles in responder and non-responder human lung tumors", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC1194408 (7 March 2022); https://doi.org/10.1117/12.2609823

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