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31 October 2023 Low-dose quantitative CT myocardial flow measurement using a single volume scan: phantom and animal validation
Logan Hubbard, Sabee Molloi
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Journal of Medical Imaging, Vol. 10, Issue 5, 056002 (October 2023). https://doi.org/10.1117/1.JMI.10.5.056002
Abstract

Purpose

To validate a low-dose, single-volume quantitative CT myocardial flow technique in a cardiovascular flow phantom and a swine animal model of coronary artery disease.

Approach

A cardiovascular flow phantom was imaged dynamically over different flow rates (0.97 to 2.45 mL / min / g) using 15 mL of contrast per injection. Six swine (37 ± 8 kg) were also imaged dynamically, with different left anterior descending coronary artery balloon stenoses assessed under intracoronary adenosine stress, using 1 mL / kg of contrast per injection. The resulting images were used to simulate dynamic bolus tracking and peak volume scan acquisition. After which, first-pass single-compartment modeling was performed to derive quantitative flow, where the pre-contrast myocardial attenuation was assumed to be spatially uniform. The accuracy of CT flow was then assessed versus ultrasound and microsphere flow in the phantom and animal models, respectively, using regression analysis.

Results

Single-volume quantitative CT flow measurements in the phantom (QCT_PHANTOM) were related to reference ultrasound flow measurements (QUS) by QCT_PHANTOM = 1.04 QUS − 0.1 (Pearson’s r = 0.98; RMSE = 0.09 mL / min / g). In the animal model (QCT_ANIMAL), they were related to reference microsphere flow measurements (QMICRO) by QCT_ANIMAL = 1.00 QMICRO − 0.05 (Pearson’s r = 0.96; RMSE = 0.48 mL / min / g). The effective dose per CT measurement was 1.21 mSv.

Conclusions

The single-volume quantitative CT flow technique only requires bolus tracking data, spatially uniform pre-contrast myocardial attenuation, and a single volume scan acquired near the peak aortic enhancement for accurate, low-dose, myocardial flow measurement (in mL/min/g) under rest and adenosine stress conditions.
© 2023 Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Logan Hubbard and Sabee Molloi "Low-dose quantitative CT myocardial flow measurement using a single volume scan: phantom and animal validation," Journal of Medical Imaging 10(5), 056002 (31 October 2023). https://doi.org/10.1117/1.JMI.10.5.056002
Received: 6 March 2023; Accepted: 16 October 2023; Published: 31 October 2023
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KEYWORDS
Computed tomography
Animals
Tissues
Blood
Microspheres
Animal model studies
Attenuation
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