Development of a movable diffuse reflectance spectroscopy system for clinical study of esophageal precancer

Yi-Hsien Hsiao; Gen-Hao Tien; Min-Jie Chuang; Fang-Wei Hsu; Hong-Po Hsieh; Kung-Bin Sung

doi:10.1117/12.2183737

15 July 2015 Development of a movable diffuse reflectance spectroscopy system for clinical study of esophageal precancer

Yi-Hsien Hsiao, Gen-Hao Tien, Min-Jie Chuang, Fang-Wei Hsu, Hong-Po Hsieh, Kung-Bin Sung

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 95371Q (2015) https://doi.org/10.1117/12.2183737
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

We constructed a movable imaging spectrograph-based system and a contact probe consisting of fibers with several source-to-detection separations (SDS) to measure spatially-resolved diffuse reflectance spectra from superficial tissue. The goal is to estimate optical properties of the mucosa in the oral cavity and investigate correlations between the estimated properties and precancerous changes in the mucosa. A previously developed GPU-based iterative curve-fitting inverse Monte Carlo model was used to extract optical properties from measured spectra. We validated the system with two-layer tissue phantoms, took in-vivo measurements on the buccal mucosa of three normal volunteers, and extracted optical parameters.

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Yi-Hsien Hsiao, Gen-Hao Tien, Min-Jie Chuang, Fang-Wei Hsu, Hong-Po Hsieh, and Kung-Bin Sung "Development of a movable diffuse reflectance spectroscopy system for clinical study of esophageal precancer", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371Q (15 July 2015); https://doi.org/10.1117/12.2183737

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