Optic disc boundary segmentation from diffeomorphic demons registration of monocular fundus image sequences versus 3D visualization of stereo fundus image pairs for automated early stage glaucoma assessment

Vijay Gatti; Jason Hill; Sunanda Mitra; Brian Nutter

doi:10.1117/12.2044291

13 March 2014 Optic disc boundary segmentation from diffeomorphic demons registration of monocular fundus image sequences versus 3D visualization of stereo fundus image pairs for automated early stage glaucoma assessment

Vijay Gatti, Jason Hill, Sunanda Mitra, Brian Nutter

Author Affiliations +

Proceedings Volume 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging; 90380H (2014) https://doi.org/10.1117/12.2044291
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Despite the current availability in resource-rich regions of advanced technologies in scanning and 3-D imaging in current ophthalmology practice, world-wide screening tests for early detection and progression of glaucoma still consist of a variety of simple tools, including fundus image-based parameters such as CDR (cup to disc diameter ratio) and CAR (cup to disc area ratio), especially in resource -poor regions. Reliable automated computation of the relevant parameters from fundus image sequences requires robust non-rigid registration and segmentation techniques. Recent research work demonstrated that proper non-rigid registration of multi-view monocular fundus image sequences could result in acceptable segmentation of cup boundaries for automated computation of CAR and CDR. This research work introduces a composite diffeomorphic demons registration algorithm for segmentation of cup boundaries from a sequence of monocular images and compares the resulting CAR and CDR values with those computed manually by experts and from 3-D visualization of stereo pairs. Our preliminary results show that the automated computation of CDR and CAR from composite diffeomorphic segmentation of monocular image sequences yield values comparable with those from the other two techniques and thus may provide global healthcare with a cost-effective yet accurate tool for management of glaucoma in its early stage.

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Vijay Gatti, Jason Hill, Sunanda Mitra, and Brian Nutter "Optic disc boundary segmentation from diffeomorphic demons registration of monocular fundus image sequences versus 3D visualization of stereo fundus image pairs for automated early stage glaucoma assessment", Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90380H (13 March 2014); https://doi.org/10.1117/12.2044291

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KEYWORDS

Image segmentation

Image registration

3D visualizations

Image visualization

Composites

Optic nerve

Head

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