Simulation of fluorescent measurements in the human skin

Igor Victorovich Meglinski; Yurii P. Sinichkin; Sergei R. Utz M.D.; Helena A. Pilipenko

doi:10.1117/12.210009

30 May 1995 Simulation of fluorescent measurements in the human skin

Igor Victorovich Meglinski, Yurii P. Sinichkin, Sergei R. Utz M.D., Helena A. Pilipenko

Proceedings Volume 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation; (1995) https://doi.org/10.1117/12.210009
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Reflectance and fluorescence spectroscopy are successfully used for skin disease diagnostics. Human skin optical parameters are defined by its turbid, scattering properties with nonuniform absorption and fluorescence chromophores distribution, its multilayered structure, and variability under different physiological and pathological conditions. Theoretical modeling of light propagation in skin could improve the understanding of these condition and may be useful in the interpretation of in vivo reflectance and autofluorescence (AF) spectra. Laser application in medical optical tomography, tissue spectroscopy, and phototherapy stimulates the development of optical and mathematical light-tissue interaction models allowing to account the specific features of laser beam and tissue inhomogeneities. This paper presents the version of a Monte Carlo method for simulating of optical radiation propagation in biotissue and highly scattering media, allowing for 3D geometry of a medium. The simulation is based on use of Green's function of medium response to single external pulse. The process of radiation propagation is studied in the area with given boundary conditions, taking into account the processes of reflection and refraction at the boundaries of layers inside the medium under study. Results of Monte Carlo simulation were compared with experimental investigations and demonstrated good agreement.

Citation Download Citation

Igor Victorovich Meglinski, Yurii P. Sinichkin, Sergei R. Utz M.D., and Helena A. Pilipenko "Simulation of fluorescent measurements in the human skin", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); https://doi.org/10.1117/12.210009

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