The development of an effective and dependable multiple description coding scheme over a lossy communication system is described. A general framework of an effective multiple description robust communication system with two-channel and four-channel cases is presented with a proposed block-based DC coefficient relocation and AC coefficient interpolation approach. A benefit of such system is that, if all the channels work properly, a very good quality, probably lossless, reconstruction can be obtained from the received descriptions. On the other hand, if some of the channels do not work properly, a lower but still quite satisfactory quality of reconstruction can be obtained. The performance of the proposed scheme is measured with mean squared error, peak signal-to-noise ratio, entropy, and bit rate to analyze the reconstruction quality, and the computed results are matched with that of the other schemes. The system complexity is also computed and compared. Comparing the simulation results, it is observed that the proposed scheme, which uses a DC coefficient relocation and AC coefficient interpolation scheme, gives comprehensive enhancements over the other recently developed schemes.